ITC0045
ITC0045
ITC0045
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- Catalog: ITC0045
- Gene/Protein: CTSL2
- Product Description: Immunotag™ Cleaved-Cathepsin L2 (L114) Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CathEPSin L2 (L114) Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Monkey Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human CATL2. AA range:95-144 Specificity Cleaved-Cathepsin L2 (L114) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin L2 protein resulting from cleavage adjacent to L114. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name CTSL2 Accession No. O60911 Alternate Names CTSL2; CATL2; CTSU; CTSV; Cathepsin L2; Cathepsin U; Cathepsin V Description cathepsin V(CTSV) Homo sapiens The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011], Cell Pathway/ Category Lysosome, Protein Expression Brain,Corneal epithelium,Kidney,Thymus, Subcellular Localization extracellular region,extracellular space,nucleolus,lysosome,microvillus,external side of plasma membrane,secretory granule,neuron projection,lysosomal lumen,perikaryon,apical part of cell,extracellular exosome, Protein Function catalytic activity:The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).,function:Cysteine protease. May have an important role in corneal physiology.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CathEPSin L2 (L114) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Monkey |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CATL2. AA range:95-144 |
| Specificity | Cleaved-Cathepsin L2 (L114) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin L2 protein resulting from cleavage adjacent to L114. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CTSL2 |
| Accession No. | O60911 |
| Alternate Names | CTSL2; CATL2; CTSU; CTSV; Cathepsin L2; Cathepsin U; Cathepsin V |
| Description | cathepsin V(CTSV) Homo sapiens The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011], |
| Cell Pathway/ Category | Lysosome, |
| Protein Expression | Brain,Corneal epithelium,Kidney,Thymus, |
| Subcellular Localization | extracellular region,extracellular space,nucleolus,lysosome,microvillus,external side of plasma membrane,secretory granule,neuron projection,lysosomal lumen,perikaryon,apical part of cell,extracellular exosome, |
| Protein Function | catalytic activity:The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).,function:Cysteine protease. May have an important role in corneal physiology.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |