ITK0062
ITK0062
- Catalog: ITK0062
- Gene/Protein: JUN
- Product Description: Immunotag™ AP-1 (Acetyl Lys271) Polyclonal Antibody
693.0000
Price in reward points: 693
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | AP-1 (Lys271) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized acetyl-peptide derived from the Internal region of human AP-1 around the acetylation site of K271. |
| Specificity | Acetyl-AP-1 (K271) Polyclonal Antibody detects endogenous levels of AP-1 protein only when acetylation at K271. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | JUN |
| Accession No. | P05412 P05627 P17325 |
| Alternate Names | JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 |
| Description | Jun proto-oncogene, AP-1 transcription factor subunit(JUN) Homo sapiens This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,ErbB_HER,WNT,WNT-T CELLFocal adhesion,Toll_Like,T_Cell_Receptor,B_Cell_Antigen,Neurotrophin,GnRH,Epithelial cell signaling in Helicobacter pylori infection,Pathways in cancer,Colorectal cancer,Renal cell carcinoma, |
| Protein Expression | B-cell,Epithelium,Ovary,Testis,Uterus, |
| Subcellular Localization | nuclear chromosome,nucleus,nucleoplasm,transcription factor complex,nuclear euchromatin,cytosol,transcriptional repressor complex, |
| Protein Function | function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|