ITM0078
ITM0078
- Catalog: ITM0078
- Gene/Protein: NPPB
- Product Description: Immunotag™ BNP Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | BNP |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Synthetic peptide corresponding to aa (Gly-Leu-Gln-Glu-Gln-Arg-Asn-His-Leu-Gln-Gly-Lys-Leu-Cys) of human BNP, conjugated to KLH. |
| Specificity | BNP Monoclonal Antibody detects endogenous levels of BNP protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | NPPB |
| Accession No. | P16860 P40753 |
| Alternate Names | NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide |
| Description | natriuretic peptide B(NPPB) Homo sapiens This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014], |
| Protein Expression | Pancreas,Spleen, |
| Subcellular Localization | extracellular region,extracellular space,protein complex, |
| Protein Function | function:Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.,online information:Brain natriuretic peptide entry,pharmaceutical:Available under the name Nesiritide (Scios). Used for the treatment of heart failure.,similarity:Belongs to the natriuretic peptide family.,subunit:Interacts with NPR3.,tissue specificity:Brain and also in atria, but at much lower levels than ANP., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|