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ITM0304

ITM0304
  • Gene/Protein: GFAP
  • Product Description: Immunotag™ GFAP Monoclonal Antibody
368.0000
Price in reward points: 368

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Immunotag™ GFAP Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein GFAP
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Mouse
Immunogen Purified recombinant fragment of human GFAP expressed in E. Coli.
Specificity GFAP Monoclonal Antibody detects endogenous levels of GFAP protein.
Purification Affinity purification
Form Ascitic fluid containing 0.03% sodium azide.
Gene Name GFAP
Accession No. P14136 P03995
Alternate Names GFAP; Glial fibrillary acidic protein; GFAP
Description glial fibrillary acidic protein(GFAP) Homo sapiens This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
Protein Expression Blood,Brain,Fetal brain,Fetal brain cortex,Kidney,
Subcellular Localization cytoplasm,lysosome,cytosol,intermediate filament,myelin sheath,cell body,intermediate filament cytoskeleton,astrocyte end-foot,cytoplasmic side of lysosomal membrane,
Protein Function Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.,online information:GFAP entry,similarity:Belongs to the intermediate filament family.,subcellular location:Associated with intermediate filaments.,subunit:Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).,tissue specificity:Expressed in cells lacking fibronectin.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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