ITM0647
ITM0647
ITM0647
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$556.00
Price in reward points: 556
- Catalog: ITM0647
- Gene/Protein: WDR5
- Product Description: Immunotag™ WDR5 Monoclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein WDR5 Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Purified recombinant fragment of human WDR5 expressed in E. Coli. Specificity WDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein. Purification Affinity purification Form Ascitic fluid containing 0.03% sodium azide. Gene Name WDR5 Accession No. P61964 P61965 Alternate Names WDR5; BIG3; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein Description WD repeat domain 5(WDR5) Homo sapiens This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008], Protein Expression Epithelium,Lung,Spleen,Uterus, Subcellular Localization histone acetyltransferase complex,nucleus,nucleoplasm,Ada2/Gcn5/Ada3 transcription activator complex,histone methyltransferase complex,MLL3/4 complex,Set1C/COMPASS complex,MLL1 complex, Protein Function function:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | WDR5 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human WDR5 expressed in E. Coli. |
| Specificity | WDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | WDR5 |
| Accession No. | P61964 P61965 |
| Alternate Names | WDR5; BIG3; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein |
| Description | WD repeat domain 5(WDR5) Homo sapiens This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008], |
| Protein Expression | Epithelium,Lung,Spleen,Uterus, |
| Subcellular Localization | histone acetyltransferase complex,nucleus,nucleoplasm,Ada2/Gcn5/Ada3 transcription activator complex,histone methyltransferase complex,MLL3/4 complex,Set1C/COMPASS complex,MLL1 complex, |
| Protein Function | function:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |