ITM1007
ITM1007
ITM1007
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- Catalog: ITM1007
- Gene/Protein: ALDH3A2
- Product Description: Immunotag™ ALDH3A2 Monoclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein ALDH3A2 Clonality Monoclonal Storage/Stability -20°C/1 year Application WB Recommended Dilution Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat,Rabbit Host Species Mouse Immunogen Purified recombinant human ALDH3A2 protein fragments expressed in Ecoli Specificity ALDH3A2 Monoclonal Antibody detects endogenous levels of ALDH3A2 protein. Purification Affinity purification Form Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Gene Name ALDH3A2 Accession No. P51648 P47740 P30839 Alternate Names ALDH3A2; ALDH10; FALDH; Fatty aldehyde dehydrogenase; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase Description aldehyde dehydrogenase 3 family member A2(ALDH3A2) Homo sapiens Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,Arginine and proline metabolism,Histidine metabolism,Tryptophan metabolism,beta-Alanine metabolism,Glycerolipid metabolism,Pyruvate metabolism,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation, Protein Expression Adrenal gland,Brain,Liver,Skin,Testis,Trachea, Subcellular Localization mitochondrial inner membrane,peroxisome,peroxisomal membrane,endoplasmic reticulum membrane,integral component of membrane,intracellular membrane-bounded organelle,extracellular exosome, Protein Function catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS) [MIM:270200]. SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.,function:Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.,similarity:Belongs to the aldehyde dehydrogenase family., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | ALDH3A2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Rabbit |
| Host Species | Mouse |
| Immunogen | Purified recombinant human ALDH3A2 protein fragments expressed in Ecoli |
| Specificity | ALDH3A2 Monoclonal Antibody detects endogenous levels of ALDH3A2 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | ALDH3A2 |
| Accession No. | P51648 P47740 P30839 |
| Alternate Names | ALDH3A2; ALDH10; FALDH; Fatty aldehyde dehydrogenase; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase |
| Description | aldehyde dehydrogenase 3 family member A2(ALDH3A2) Homo sapiens Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,Arginine and proline metabolism,Histidine metabolism,Tryptophan metabolism,beta-Alanine metabolism,Glycerolipid metabolism,Pyruvate metabolism,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation, |
| Protein Expression | Adrenal gland,Brain,Liver,Skin,Testis,Trachea, |
| Subcellular Localization | mitochondrial inner membrane,peroxisome,peroxisomal membrane,endoplasmic reticulum membrane,integral component of membrane,intracellular membrane-bounded organelle,extracellular exosome, |
| Protein Function | catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS) [MIM:270200]. SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.,function:Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.,similarity:Belongs to the aldehyde dehydrogenase family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |