ITM1016
ITM1016
ITM1016
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- Catalog: ITM1016
- Gene/Protein: BECN1
- Product Description: Immunotag™ Beclin-1 Monoclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein Beclin-1 Clonality Monoclonal Storage/Stability -20°C/1 year Application WB Recommended Dilution Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse,Rat,Pig,Rabbit Host Species Mouse Immunogen Purified recombinant human Beclin-1 protein fragments expressed in Ecoli Specificity Beclin-1 Monoclonal Antibody detects endogenous levels of Beclin-1 protein. Purification Affinity purification Form Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Gene Name BECN1 Accession No. Q14457 O88597 Q91XJ1 Alternate Names BECN1; GT197; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 Description beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], Cell Pathway/ Category Regulation of autophagy, Protein Expression Brain,Cervix,Mammary gland, Subcellular Localization pre-autophagosomal structure,nucleus,mitochondrion,endosome,autophagosome,endoplasmic reticulum,endoplasmic reticulum membrane,trans-Golgi network,cytosol,endosome membrane,cytoplasmic, membrane-bounded vesicle,extrinsic component of membrane,G Protein Function function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | Beclin-1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Pig,Rabbit |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Beclin-1 protein fragments expressed in Ecoli |
| Specificity | Beclin-1 Monoclonal Antibody detects endogenous levels of Beclin-1 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | BECN1 |
| Accession No. | Q14457 O88597 Q91XJ1 |
| Alternate Names | BECN1; GT197; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 |
| Description | beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
| Cell Pathway/ Category | Regulation of autophagy, |
| Protein Expression | Brain,Cervix,Mammary gland, |
| Subcellular Localization | pre-autophagosomal structure,nucleus,mitochondrion,endosome,autophagosome,endoplasmic reticulum,endoplasmic reticulum membrane,trans-Golgi network,cytosol,endosome membrane,cytoplasmic, membrane-bounded vesicle,extrinsic component of membrane,G |
| Protein Function | function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |