ITM1037
ITM1037
- Catalog: ITM1037
- Gene/Protein: FYB
- Product Description: Immunotag™ Fyb Monoclonal Antibody
504.0000
Price in reward points: 504
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Antibody Specification | |
Datasheet | |
Target Protein | Fyb |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Rat |
Host Species | Mouse |
Immunogen | Purified recombinant human Fyb protein fragments expressed in E.coli. |
Specificity | Fyb Monoclonal Antibody detects endogenous levels of Fyb protein. |
Purification | Affinity purification |
Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
Gene Name | FYB |
Accession No. | O15117 O35601 |
Alternate Names | FYB; SLAP130; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein |
Description | FYN binding protein(FYB) Homo sapiens The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011], |
Protein Expression | Cerebellum,Liver,Platelet,Skin,Tonsil, |
Subcellular Localization | nucleus,cytosol,plasma membrane,actin cytoskeleton,cell junction, |
Protein Function | function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |