ITM1042
ITM1042
ITM1042
from
$556.00
Price in reward points: 556
- Catalog: ITM1042
- Gene/Protein: ST13
- Product Description: Immunotag™ Hip Monoclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein Hip Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,IHC-p,IF Recommended Dilution Western Blot: 1/1000 - 1/2000. Immunohistochemistry: 1/500 - 1/1000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Bovine,Dog,Pig Host Species Mouse Immunogen Purified recombinant human Hip protein fragments expressed in E.coli. Specificity Hip Monoclonal Antibody detects endogenous levels of Hip protein. Purification Affinity purification Form Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Gene Name ST13 Accession No. P50502 Q99L47 Alternate Names ST13; AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tum Description suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)(ST13) Homo sapiens The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013], Protein Expression Colon mucosa,Epithelium,Fet Subcellular Localization cytoplasm,cytosol,protein complex,extracellular exosome, Protein Function function:One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.,similarity:Belongs to the FAM10 family.,similarity:Contains 1 STI1 domain.,similarity:Contains 3 TPR repeats.,subunit:Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | Hip |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Immunohistochemistry: 1/500 - 1/1000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Bovine,Dog,Pig |
| Host Species | Mouse |
| Immunogen | Purified recombinant human Hip protein fragments expressed in E.coli. |
| Specificity | Hip Monoclonal Antibody detects endogenous levels of Hip protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | ST13 |
| Accession No. | P50502 Q99L47 |
| Alternate Names | ST13; AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tum |
| Description | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)(ST13) Homo sapiens The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013], |
| Protein Expression | Colon mucosa,Epithelium,Fet |
| Subcellular Localization | cytoplasm,cytosol,protein complex,extracellular exosome, |
| Protein Function | function:One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.,similarity:Belongs to the FAM10 family.,similarity:Contains 1 STI1 domain.,similarity:Contains 3 TPR repeats.,subunit:Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |