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ITM1080

ITM1080
  • Gene/Protein: PPP3CA
  • Product Description: Immunotag™ PP2B-Aα Monoclonal Antibody
368.0000
Price in reward points: 368

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Immunotag™ PP2B-Aα Monoclonal Antibody
Antibody Specification
Datasheet
Target Protein PP2B-Aα
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB
Recommended Dilution Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Mouse
Immunogen Purified recombinant human PP2B-Aα protein fragments expressed in Ecoli
Specificity PP2B-Aα Monoclonal Antibody detects endogenous levels of PP2B-Aα protein.
Purification Affinity purification
Form Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Gene Name PPP3CA
Accession No. Q08209 P63328 P63329
Alternate Names PPP3CA; CALNA; CNA; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform
Description catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,
Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Calcium,Oocyte meiosis,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,WNT,WNT-T CELLAxon guidance,VEGF,Natural killer cell mediated cytotoxicity,T_Cell_Receptor,B_Cell_Antigen,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS),
Protein Expression Amygdala,Brain,Pancreas,
Subcellular Localization nucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol,calcineurin complex,membrane,Z disc,sarcolemma,postsynapse,
Protein Function catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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