ITM1084
ITM1084
- Catalog: ITM1084
- Gene/Protein: PRMT1
- Product Description: Immunotag™ PRMT1 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PRMT1 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Dog,Rabbit |
| Host Species | Mouse |
| Immunogen | Purified recombinant human PRMT1 protein fragments expressed in Ecoli |
| Specificity | PRMT1 Monoclonal Antibody detects endogenous levels of PRMT1 protein. |
| Purification | Affinity purification |
| Form | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. |
| Gene Name | PRMT1 |
| Accession No. | Q99873 Q9JIF0 Q63009 |
| Alternate Names | PRMT1; HMT2; HRMT1L2; IR1B4; Protein arginine N-methyltransferase 1; Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4 |
| Description | protein arginine methyltransferase 1(PRMT1) Homo sapiens This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011], |
| Protein Expression | Glial cell,Lung, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,cytosol,methylosome, |
| Protein Function | enzyme regulation:By BTG1, BTG2 and ILF3.,function:Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H and EWS.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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