ITM1243
ITM1243
ITM1243
from
$447.00
Price in reward points: 447
- Catalog: ITM1243
- Gene/Protein: gapdh
- Product Description: Immunotag™ GAPDH(Human specific) mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein GAPDH (Hu) Clonality Monoclonal Storage/Stability -20°C/1 year Application WB Recommended Dilution wb 1:5000 Concentration 1 mg/ml Reactive Species Human,Monkey Host Species Mouse Immunogen Purified recombinant human GAPDH protein fragments expressed in E.coli. Specificity This antibody detects endogenous levels of human GAPDH and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name gapdh Accession No. P04406 P16858 Alternate Names 38 kDa BFA-dependent ADP-ribosylation substrate;aging associated gene 9 protein;Aging-associated gene 9 protein;BARS-38;cb609;EC 1.2.1.12;G3P_HUMAN;G3PD;G3PDH;GAPD;GAPDH; GAPDH;Glyceraldehyde 3 phosphate dehydrogenase;Glyceraldehyde 3 phosphate dehydrogenase liver;Glyceraldehyde 3 phosphate dehydrogenase muscle;Glyceraldehyde-3-phosphate dehydrogenase;KNC-NDS6;MGC102544;MGC102546;MGC103190;MGC103191;MGC105239;MGC127711; MGC88685;OCAS, p38 component;OCT1 coactivator in S phase, 38-KD component;peptidyl cysteine S nitrosylase GAPDH;Peptidyl-cysteine S-nitrosylase GAPDH;wu:fb33a10. Description glyceraldehyde-3-phosphate dehydrogenase(GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferri Cell Pathway/ Category Glycolysis / Gluconeogenesis,Alzheimer's disease, Protein Expression Astrocytoma,Brain,Cajal-Retzius cell,Colon adenocarcinoma,Epitheliu Subcellular Localization nucleus,cytoplasm,lipid particle,cytosol,plasma membrane,microtubule cytoskeleton,membrane,intracellular ribonucleoprotein complex,extracellular matrix,nuclear membrane,vesicle,intracellular membrane-bounded orga Protein Function catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.,function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.,online information:Glyceraldehyde 3-phosphate dehydrogenase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis.,sequence caution:Differs quite extensively.,similarity:Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.,subcellular location:Postnuclear and Perinuclear regions.,subunit:Homotetramer.,subunit:Homotetramer. Binds PRKCI., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | GAPDH (Hu) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:5000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Monkey |
| Host Species | Mouse |
| Immunogen | Purified recombinant human GAPDH protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of human GAPDH and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | gapdh |
| Accession No. | P04406 P16858 |
| Alternate Names | 38 kDa BFA-dependent ADP-ribosylation substrate;aging associated gene 9 protein;Aging-associated gene 9 protein;BARS-38;cb609;EC 1.2.1.12;G3P_HUMAN;G3PD;G3PDH;GAPD;GAPDH; GAPDH;Glyceraldehyde 3 phosphate dehydrogenase;Glyceraldehyde 3 phosphate dehydrogenase liver;Glyceraldehyde 3 phosphate dehydrogenase muscle;Glyceraldehyde-3-phosphate dehydrogenase;KNC-NDS6;MGC102544;MGC102546;MGC103190;MGC103191;MGC105239;MGC127711; MGC88685;OCAS, p38 component;OCT1 coactivator in S phase, 38-KD component;peptidyl cysteine S nitrosylase GAPDH;Peptidyl-cysteine S-nitrosylase GAPDH;wu:fb33a10. |
| Description | glyceraldehyde-3-phosphate dehydrogenase(GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferri |
| Cell Pathway/ Category | Glycolysis / Gluconeogenesis,Alzheimer's disease, |
| Protein Expression | Astrocytoma,Brain,Cajal-Retzius cell,Colon adenocarcinoma,Epitheliu |
| Subcellular Localization | nucleus,cytoplasm,lipid particle,cytosol,plasma membrane,microtubule cytoskeleton,membrane,intracellular ribonucleoprotein complex,extracellular matrix,nuclear membrane,vesicle,intracellular membrane-bounded orga |
| Protein Function | catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.,function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.,online information:Glyceraldehyde 3-phosphate dehydrogenase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis.,sequence caution:Differs quite extensively.,similarity:Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.,subcellular location:Postnuclear and Perinuclear regions.,subunit:Homotetramer.,subunit:Homotetramer. Binds PRKCI., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |