ITM1247
ITM1247
ITM1247
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Price in reward points: 447
- Catalog: ITM1247
- Gene/Protein: hspa5
- Product Description: Immunotag™ BiP/GRP78(C-term) mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein BiP/GRP78 (C-term) Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,ICC,IHC Recommended Dilution wb 1:1000 icc 1:50 Concentration 1 mg/ml Reactive Species Human,Rat Host Species Mouse Immunogen Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli. Specificity This antibody detects endogenous levels of BiP/GRP78 (C-terminus) and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name hspa5 Accession No. P11021 P20029 Alternate Names 78 kDa glucose regulated protein;78 kDa glucose-regulated protein;AL022860;AU019543;BIP; D2Wsu141e;D2Wsu17e;Endoplasmic reticulum lumenal Ca(2 )-binding protein grp78; Endoplasmic reticulum lumenal Ca2 binding protein grp78;FLJ26106;Glucose Regulated Protein 78kDa;GRP 78;GRP-78;GRP78;GRP78_HUMAN;Heat shock 70 kDa protein 5;Heat Shock 70kDa Protein 5;Hsce70;HSPA 5;HSPA5;Immunoglobulin Heavy Chain Binding Protein; Immunoglobulin heavy chain-binding protein;mBiP;MIF2;Sez7. Description heat shock protein family A (Hsp70) member 5(HSPA5) Homo sapiens The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010], Cell Pathway/ Category Antigen processing and presentation,Prion diseases, Protein Expression Articular cartilage,Brain,Cajal-Retzius cell,Cervix carcino Subcellular Localization nucleus,mitochondrion,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,smooth endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,cell-cell adherens junction, Protein Function disease:Autoantigen in rheumatoid arthritis [MIM:180300].,function:Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | BiP/GRP78 (C-term) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC,IHC |
| Recommended Dilution | wb 1:1000 icc 1:50 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of BiP/GRP78 (C-terminus) and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | hspa5 |
| Accession No. | P11021 P20029 |
| Alternate Names | 78 kDa glucose regulated protein;78 kDa glucose-regulated protein;AL022860;AU019543;BIP; D2Wsu141e;D2Wsu17e;Endoplasmic reticulum lumenal Ca(2 )-binding protein grp78; Endoplasmic reticulum lumenal Ca2 binding protein grp78;FLJ26106;Glucose Regulated Protein 78kDa;GRP 78;GRP-78;GRP78;GRP78_HUMAN;Heat shock 70 kDa protein 5;Heat Shock 70kDa Protein 5;Hsce70;HSPA 5;HSPA5;Immunoglobulin Heavy Chain Binding Protein; Immunoglobulin heavy chain-binding protein;mBiP;MIF2;Sez7. |
| Description | heat shock protein family A (Hsp70) member 5(HSPA5) Homo sapiens The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010], |
| Cell Pathway/ Category | Antigen processing and presentation,Prion diseases, |
| Protein Expression | Articular cartilage,Brain,Cajal-Retzius cell,Cervix carcino |
| Subcellular Localization | nucleus,mitochondrion,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,smooth endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,cell-cell adherens junction, |
| Protein Function | disease:Autoantigen in rheumatoid arthritis [MIM:180300].,function:Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |