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  • Gene/Protein: ppp2cb
  • Product Description: Immunotag™ PP2A α and β mouse mAb
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Immunotag™ PP2A α and β mouse mAb
Antibody Specification
Target Protein PP2A α & β
Clonality Monoclonal
Storage/Stability -20°C/1 year
Application WB,IP
Recommended Dilution wb 1:2000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Mouse
Immunogen Purified recombinant human full length PP2A beta protein expressed in E.coli
Specificity This antibody detects endogenous levels of PP2A alpha and PP2A beta.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name ppp2cb
Accession No. P62714 P62715
Alternate Names PP2A beta;PP2A-beta;PP2AB_HUMAN;PP2Abeta;PP2CB;Ppp2cb;Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform;Protein phosphatase 2 catalytic subunit beta isozyme;Protein phosphatase 2, catalytic subunit, beta isoform;Protein phosphatase 2A catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Serine/threonine protein phosphatase 2A catalytic subunit beta;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.
Description protein phosphatase 2 catalytic subunit beta(PPP2CB) Homo sapiens This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010],
Cell Pathway/ Category Oocyte meiosis,WNT,WNT-T CELLTGF-beta,Tight junction,Long-term depression,
Protein Expression Fibroblast,Heart,Kidney,Liver,
Subcellular Localization protein phosphatase type 2A complex,chromosome, centromeric region,spindle pole,nucleus,cytoplasm,cytosol,extracellular exosome,
Protein Function catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.,PTM:Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.,PTM:Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subcellular location:In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.,subunit:PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet

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