ITM1268
ITM1268
ITM1268
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$447.00
Price in reward points: 447
- Catalog: ITM1268
- Gene/Protein: ppp1ca
- Product Description: Immunotag™ PPP1A mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PPP1A Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,ICC Recommended Dilution wb 1:1000 icc 1:50 Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Purified recombinant human PPP1A protein fragments expressed in E.coli. Specificity This antibody detects endogenous levels of PPP1A and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name ppp1ca Accession No. P62136 P62137 Alternate Names Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit;EC 3.1.3.16;MGC15877;MGC1674;PP 1A;PP-1A;PP1A;PP1A_HUMAN;PP1alpha;PP2C ALPHA;PP2CA;Ppp1ca;Protein Phosphatase 2C Alpha Isoform;Serine threonine protein phosphatase PP1 alpha catalytic subunit;Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit. Description protein phosphatase 1 catalytic subunit alpha(PPP1CA) Homo sapiens The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Oocyte meiosis,Vascular smooth muscle contraction,Focal adhesion,Long-term potentiation,Regulates Actin and Cytoskeleton,Insulin_Receptor, Protein Expression Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele Subcellular Localization protein phosphatase type 1 complex,nuclear chromosome, telomeric region,nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,plasma membrane,cell-cell junction,glycogen granule,dendritic spine,perikaryon, Protein Function catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PPP1A |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:50 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human PPP1A protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of PPP1A and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ppp1ca |
| Accession No. | P62136 P62137 |
| Alternate Names | Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit;EC 3.1.3.16;MGC15877;MGC1674;PP 1A;PP-1A;PP1A;PP1A_HUMAN;PP1alpha;PP2C ALPHA;PP2CA;Ppp1ca;Protein Phosphatase 2C Alpha Isoform;Serine threonine protein phosphatase PP1 alpha catalytic subunit;Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit. |
| Description | protein phosphatase 1 catalytic subunit alpha(PPP1CA) Homo sapiens The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Oocyte meiosis,Vascular smooth muscle contraction,Focal adhesion,Long-term potentiation,Regulates Actin and Cytoskeleton,Insulin_Receptor, |
| Protein Expression | Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele |
| Subcellular Localization | protein phosphatase type 1 complex,nuclear chromosome, telomeric region,nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,plasma membrane,cell-cell junction,glycogen granule,dendritic spine,perikaryon, |
| Protein Function | catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |