ITM1271
ITM1271
ITM1271
from
$447.00
Price in reward points: 447
- Catalog: ITM1271
- Gene/Protein: sirt2
- Product Description: Immunotag™ SirT2 mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein SIRT2 Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,IF Recommended Dilution wb 1:1000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Mouse Immunogen Purified recombinant human SirT2 protein expressed in E.coli. Specificity This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name sirt2 Accession No. Q8IXJ6 Q8VDQ8 Alternate Names FLJ35621;FLJ37491;NAD dependent deacetylase sirtuin 2;NAD-dependent deacetylase sirtuin-2;NAD-dependent protein deacetylase sirtuin-2;Regulatory protein SIR2 homolog 2;Silencing information regulator 2 like;Silent information regulator 2;Silent mating type information regulation 2;Silent mating type information regulation 2 homolog;SIR 2;SIR2;SIR2 like;SIR2 like protein 2;Sir2 related protein type 2;SIR2, S. cerevisiae, homolog-loke 2;SIR2-like protein 2;SIR2L;SIR2L2;SIRT 2;SIRT2;SIRT2_HUMAN;Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae);Sirtuin 2;Sirtuin type 2;Sirtuin2. Description sirtuin 2(SIRT2) Homo sapiens This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010], Protein Expression Adrenal gland,Brain,Lung,Platelet,Testis, Subcellular Localization chromosome, telomeric region,nucleus,chromatin silencing complex,chromosome,nuclear heterochromatin,cytoplasm,centrosome,centriole,spindle,cytosol,microtubule,plasma membrane,growth cone,midbody,paranoda Protein Function catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.,enzyme regulation:Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide.,function:NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Phosphorylated at the G2/M transition of the cell cycle.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Colocalizes with microtubules.,subunit:Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.,tissue specificity:Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | SIRT2 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Mouse |
| Immunogen | Purified recombinant human SirT2 protein expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | sirt2 |
| Accession No. | Q8IXJ6 Q8VDQ8 |
| Alternate Names | FLJ35621;FLJ37491;NAD dependent deacetylase sirtuin 2;NAD-dependent deacetylase sirtuin-2;NAD-dependent protein deacetylase sirtuin-2;Regulatory protein SIR2 homolog 2;Silencing information regulator 2 like;Silent information regulator 2;Silent mating type information regulation 2;Silent mating type information regulation 2 homolog;SIR 2;SIR2;SIR2 like;SIR2 like protein 2;Sir2 related protein type 2;SIR2, S. cerevisiae, homolog-loke 2;SIR2-like protein 2;SIR2L;SIR2L2;SIRT 2;SIRT2;SIRT2_HUMAN;Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae);Sirtuin 2;Sirtuin type 2;Sirtuin2. |
| Description | sirtuin 2(SIRT2) Homo sapiens This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010], |
| Protein Expression | Adrenal gland,Brain,Lung,Platelet,Testis, |
| Subcellular Localization | chromosome, telomeric region,nucleus,chromatin silencing complex,chromosome,nuclear heterochromatin,cytoplasm,centrosome,centriole,spindle,cytosol,microtubule,plasma membrane,growth cone,midbody,paranoda |
| Protein Function | catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.,enzyme regulation:Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide.,function:NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Phosphorylated at the G2/M transition of the cell cycle.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Colocalizes with microtubules.,subunit:Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.,tissue specificity:Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |