ITM1279
ITM1279
- Catalog: ITM1279
- Gene/Protein: foxo1
- Product Description: Immunotag™ FOXO1(C-term) mouse mAb
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FOXO1 (C-term) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human FOXO1(C-terminus) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of FOXO1(C-terminus) and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | foxo1 |
| Accession No. | Q12778 Q9R1E0 |
| Alternate Names | FKH 1;FKH1;FKH1;FKHR;FKHR;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead box O1;Forkhead box protein O1; Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead, Drosophila, homolog of, in rhabdomyosarcoma;FOXO1;FOXO1;FOXO1_HUMAN;FOXO1A;OTTHUMP00000018301. |
| Description | forkhead box O1(FOXO1) Homo sapiens This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Insulin_Receptor,Pathways in cancer,Prostate cancer, |
| Protein Expression | Lymph,Placenta,Rhabdomyosarcoma, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol, |
| Protein Function | disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.,function:Transcription factor.,PTM:Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Interacts with LRPPRC.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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