ITM1295
ITM1295
- Catalog: ITM1295
- Gene/Protein: eef2
- Product Description: Immunotag™ eEF2 mouse mAb
405.0000
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Antibody Specification | |
Datasheet | |
Target Protein | EEF2 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ICC |
Recommended Dilution | wb 1:5000 icc 1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant human eEF2 protein fragments expressed in E.coli. |
Specificity | This antibody detects endogenous levels of eEF2 and does not cross-react with related proteins. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | eef2 |
Accession No. | P13639 P58252 |
Alternate Names | EEF2;Eef2;EF-2;EF2;EF2_HUMAN;Elongation factor 2;Eukaryotic translation elongation factor 2;Polypeptidyl tRNA translocase;SCA26. |
Description | eukaryotic translation elongation factor 2(EEF2) Homo sapiens This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008], |
Protein Expression | Brain,Cajal-Retzius cell,Epithelium,Hepatocyte,Ovary,Periph |
Subcellular Localization | nucleus,cytoplasm,cytosol,plasma membrane,cell-cell adherens junction,membrane,aggresome,intracellular ribonucleoprotein complex,extracellular matrix,polysomal ribosome,membrane raft,extracellular exosome |
Protein Function | function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.,PTM:Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |