ITM1321
ITM1321
ITM1321
from
$447.00
Price in reward points: 447
- Catalog: ITM1321
- Gene/Protein: fyb
- Product Description: Immunotag™ FYB mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein FYB Clonality Monoclonal Storage/Stability -20°C/1 year Application WB Recommended Dilution wb 1:500 Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Purified recombinant human FYB protein fragments expressed in E.coli. Specificity This antibody detects endogenous levels of FYB and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name fyb Accession No. O15117 O35601 Alternate Names ADAP;Adhesion and degranulation promoting adaptor protein;FYB 120/130;Fyb;FYB-120/130; FYB_HUMAN;FYN binding protein;FYN T binding protein;FYN-binding protein;FYN-T-binding protein;p120/p130;PRO0823;SLAP 130;SLAP-130;SLAP130;SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein;SLP76 associated phosphoprotein. Description FYN binding protein(FYB) Homo sapiens The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011], Protein Expression Cerebellum,Liver,Platelet,Skin,Tonsil, Subcellular Localization nucleus,cytosol,plasma membrane,actin cytoskeleton,cell junction, Protein Function function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | FYB |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | wb 1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human FYB protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of FYB and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | fyb |
| Accession No. | O15117 O35601 |
| Alternate Names | ADAP;Adhesion and degranulation promoting adaptor protein;FYB 120/130;Fyb;FYB-120/130; FYB_HUMAN;FYN binding protein;FYN T binding protein;FYN-binding protein;FYN-T-binding protein;p120/p130;PRO0823;SLAP 130;SLAP-130;SLAP130;SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein;SLP76 associated phosphoprotein. |
| Description | FYN binding protein(FYB) Homo sapiens The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011], |
| Protein Expression | Cerebellum,Liver,Platelet,Skin,Tonsil, |
| Subcellular Localization | nucleus,cytosol,plasma membrane,actin cytoskeleton,cell junction, |
| Protein Function | function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |