ITM1345
ITM1345
ITM1345
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- Catalog: ITM1345
- Gene/Protein: uchl1
- Product Description: Immunotag™ UCHL1/PGP9.5 mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein UCHL1/PGP9.5 Clonality Monoclonal Storage/Stability -20°C/1 year Application WB,ICC Recommended Dilution wb 1:1000 icc 1:300 Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Purified recombinant human UCHL1 / PGP9.5 protein fragments expressed in E.coli. Specificity This antibody detects endogenous levels of UCHL1 / PGP9.5 and does not cross-react with related proteins. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name uchl1 Accession No. P09936 Q9R0P9 Alternate Names UCHL1 / PGP9.5;UCHL1;B220;CD 45;CD45;cd45 antigen;ec3.1.3.48;GP 180;GP180;Human homolog of severe combined immunodeficiency due to PTPRC deficiency;L CA;L-CA;lca;Leukocyte common antigen;LY 5;LY5;Protein tyrosine phosphatase receptor type C;Protein tyrosine phosphatase receptor type c polypeptide;PTPRC;PTPRC_HUMAN;Receptor-type tyrosine-protein phosphatase C;SCID due to PTPRC deficiency;t200;T200 glycoprotein;T200 leukocyte common antigen. Description ubiquitin C-terminal hydrolase L1(UCHL1) Homo sapiens The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009], Cell Pathway/ Category Parkinson's disease, Protein Expression Brain,Cajal-Retzius cell,Fetal brain cortex,Lung,Muscle, Subcellular Localization intracellular,nucleoplasm,cytoplasm,endoplasmic reticulum membrane,cytosol,plasma membrane,neuronal cell body,myelin sheath,neuron projection terminus,extracellular exosome,axon cytoplasm, Protein Function catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,disease:Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.,function:Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.,miscellaneous:In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.,online information:Ubiquitin carboxy-terminal hydrolase L1 entry,PTM:O-glycosylated.,similarity:Belongs to the peptidase C12 family.,subunit:Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.,tissue specificity:Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | UCHL1/PGP9.5 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ICC |
| Recommended Dilution | wb 1:1000 icc 1:300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant human UCHL1 / PGP9.5 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of UCHL1 / PGP9.5 and does not cross-react with related proteins. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | uchl1 |
| Accession No. | P09936 Q9R0P9 |
| Alternate Names | UCHL1 / PGP9.5;UCHL1;B220;CD 45;CD45;cd45 antigen;ec3.1.3.48;GP 180;GP180;Human homolog of severe combined immunodeficiency due to PTPRC deficiency;L CA;L-CA;lca;Leukocyte common antigen;LY 5;LY5;Protein tyrosine phosphatase receptor type C;Protein tyrosine phosphatase receptor type c polypeptide;PTPRC;PTPRC_HUMAN;Receptor-type tyrosine-protein phosphatase C;SCID due to PTPRC deficiency;t200;T200 glycoprotein;T200 leukocyte common antigen. |
| Description | ubiquitin C-terminal hydrolase L1(UCHL1) Homo sapiens The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009], |
| Cell Pathway/ Category | Parkinson's disease, |
| Protein Expression | Brain,Cajal-Retzius cell,Fetal brain cortex,Lung,Muscle, |
| Subcellular Localization | intracellular,nucleoplasm,cytoplasm,endoplasmic reticulum membrane,cytosol,plasma membrane,neuronal cell body,myelin sheath,neuron projection terminus,extracellular exosome,axon cytoplasm, |
| Protein Function | catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,disease:Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.,function:Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.,miscellaneous:In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.,online information:Ubiquitin carboxy-terminal hydrolase L1 entry,PTM:O-glycosylated.,similarity:Belongs to the peptidase C12 family.,subunit:Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.,tissue specificity:Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |