ITM3346
ITM3346
ITM3346
from
$447.00
Price in reward points: 447
- Catalog: ITM3346
- Gene/Protein: PGC
- Product Description: Immunotag™ PEPC Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PEPC Clonality Polyclonal Storage/Stability -20°C/1 year Application WB Recommended Dilution WB: 1:2000-5000 Concentration 1 mg/ml Reactive Species Plants Host Species Rabbit Immunogen Synthetic Peptide of PEPC Specificity The antibody detects endogenous PEPC protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Form PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Gene Name PGC Accession No. P20142 Q9D7R7 P04073 Alternate Names PGC; Gastricsin; Pepsinogen C Description progastricsin(PGC) Homo sapiens This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009], Protein Expression Brain,Liver,Placenta,Stomach, Subcellular Localization extracellular space,extracellular exosome, Protein Function catalytic activity:More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.,function:Hydrolyzes a variety of proteins.,similarity:Belongs to the peptidase A1 family., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PEPC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB |
| Recommended Dilution | WB: 1:2000-5000 |
| Concentration | 1 mg/ml |
| Reactive Species | Plants |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of PEPC |
| Specificity | The antibody detects endogenous PEPC protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | PGC |
| Accession No. | P20142 Q9D7R7 P04073 |
| Alternate Names | PGC; Gastricsin; Pepsinogen C |
| Description | progastricsin(PGC) Homo sapiens This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009], |
| Protein Expression | Brain,Liver,Placenta,Stomach, |
| Subcellular Localization | extracellular space,extracellular exosome, |
| Protein Function | catalytic activity:More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.,function:Hydrolyzes a variety of proteins.,similarity:Belongs to the peptidase A1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |