ITM3447
ITM3447
- Catalog: ITM3447
- Gene/Protein: PRKAB2
- Product Description: Immunotag™ AMPKβ2 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | AMPKβ2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | WB: 1:1000-2000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Recombinant Protein of AMPKβ2 |
Specificity | The antibody detects endogenous AMPKβ2 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Gene Name | PRKAB2 |
Accession No. | O43741 Q6PAM0 Q9QZH4 |
Alternate Names | PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2 |
Description | protein kinase AMP-activated non-catalytic subunit beta 2(PRKAB2) Homo sapiens The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013], |
Cell Pathway/ Category | Insulin_Receptor,Adipocytokine,Hypertrophic cardiomyopathy (HCM), |
Protein Expression | Liver,Pancreas, |
Subcellular Localization | nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
Protein Function | function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |