ITM3494
ITM3494
ITM3494
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- Catalog: ITM3494
- Gene/Protein: CACNA2D1
- Product Description: Immunotag™ CaVα2δ1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CaVα2δ1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC-p Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Rat Host Species Rabbit Immunogen Synthetic Peptide of CaVα2δ1 Specificity The antibody detects endogenous CaVα2δ1 protein Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name CACNA2D1 Accession No. P54289 O08532 P54290 Alternate Names Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] Description calcium voltage-gated channel auxiliary subunit alpha2delta 1(CACNA2D1) Homo sapiens The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014], Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Cardiac muscle contraction,Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, Protein Expression Brain,Liver,Plasma, Subcellular Localization plasma membrane,voltage-gated calcium channel complex,sarcoplasmic reticulum,extracellular exosome,L-type voltage-gated calcium channel complex, Protein Function domain:The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.,function:The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.,miscellaneous:Binds gabapentin, an antiepileptic drug.,PTM:Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.,similarity:Belongs to the calcium channel subunit alpha-2/delta family.,similarity:Contains 1 cache domain.,similarity:Contains 1 VWFA domain.,subunit:Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio.,tissue specificity:Central nervous system, skeletal muscle and aorta tissues., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CaVα2δ1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Rat |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of CaVα2δ1 |
| Specificity | The antibody detects endogenous CaVα2δ1 protein |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CACNA2D1 |
| Accession No. | P54289 O08532 P54290 |
| Alternate Names | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] |
| Description | calcium voltage-gated channel auxiliary subunit alpha2delta 1(CACNA2D1) Homo sapiens The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Cardiac muscle contraction,Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, |
| Protein Expression | Brain,Liver,Plasma, |
| Subcellular Localization | plasma membrane,voltage-gated calcium channel complex,sarcoplasmic reticulum,extracellular exosome,L-type voltage-gated calcium channel complex, |
| Protein Function | domain:The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.,function:The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.,miscellaneous:Binds gabapentin, an antiepileptic drug.,PTM:Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.,similarity:Belongs to the calcium channel subunit alpha-2/delta family.,similarity:Contains 1 cache domain.,similarity:Contains 1 VWFA domain.,subunit:Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio.,tissue specificity:Central nervous system, skeletal muscle and aorta tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |