ITM3512
ITM3512
ITM3512
from
$447.00
Price in reward points: 447
- Catalog: ITM3512
- Gene/Protein: PPIB
- Product Description: Immunotag™ Cyclophilin B Monoclonal Antibody(2B10)
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CyclophIL-in B (2B10) Clonality Monoclonal Storage/Stability -20°C/1 year Application IF,WB,IHC-p, Recommended Dilution IF: 1:50-200 WB 1:1000-2000 IHC 1:50-300 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Mouse Immunogen Synthetic Peptide of Cyclophilin B Specificity Cyclophilin B protein detects endogenous levels of Cyclophilin B Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name PPIB Accession No. P23284 P24369 P24368 Alternate Names PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP Description peptidylprolyl isomerase B(PPIB) Homo sapiens The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009], Protein Expression Brain,Fetal brain cortex,Prostate,Skin, Subcellular Localization nucleus,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,focal adhesion,membrane,macromolecular complex,endoplasmic reticulum chaperone complex,melanosome,perinuclear region of cytoplasm,extracellular Protein Function catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CyclophIL-in B (2B10) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,WB,IHC-p, |
| Recommended Dilution | IF: 1:50-200 WB 1:1000-2000 IHC 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Mouse |
| Immunogen | Synthetic Peptide of Cyclophilin B |
| Specificity | Cyclophilin B protein detects endogenous levels of Cyclophilin B |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPIB |
| Accession No. | P23284 P24369 P24368 |
| Alternate Names | PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| Description | peptidylprolyl isomerase B(PPIB) Homo sapiens The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009], |
| Protein Expression | Brain,Fetal brain cortex,Prostate,Skin, |
| Subcellular Localization | nucleus,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,focal adhesion,membrane,macromolecular complex,endoplasmic reticulum chaperone complex,melanosome,perinuclear region of cytoplasm,extracellular |
| Protein Function | catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |