ITM3517
ITM3517
ITM3517
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- Catalog: ITM3517
- Gene/Protein: CAMK2B
- Product Description: Immunotag™ CaMKIIβ/γ/δ (Phospho Thr287) Monoclonal Antibody(4H2)
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CAMK2β/γ/δ (Thr287) Clonality Monoclonal Storage/Stability -20°C/1 year Application IHC-p Recommended Dilution IHC: 1:100-200 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Mouse Immunogen Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287) Specificity CaMKIIβ/γ/δ (Phospho Thr287) protein detects endogenous levels of CaMKIIβ/γ/δ (Phospho Thr287) Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen Form Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide Gene Name CAMK2B Accession No. Q13554/Q13555/Q13557 Alternate Names CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; Description calcium/calmodulin dependent protein kinase II beta(CAMK2B) Homo sapiens The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], Cell Pathway/ Category ErbB_HER,Calcium,Oocyte meiosis,WNT,WNT-T CELLLong-term potentiation,Neurotrophin,Olfactory transduction,GnRH,Melanogenesis,Glioma, Protein Expression Brain,Insulinoma,Lung,Skeletal muscle, Subcellular Localization nucleoplasm,microtubule organizing center,cytosol,plasma membrane,endocytic vesicle membrane,sarcoplasmic reticulum membrane, Protein Function The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CAMK2β/γ/δ (Thr287) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC: 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Mouse |
| Immunogen | Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287) |
| Specificity | CaMKIIβ/γ/δ (Phospho Thr287) protein detects endogenous levels of CaMKIIβ/γ/δ (Phospho Thr287) |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Gene Name | CAMK2B |
| Accession No. | Q13554/Q13555/Q13557 |
| Alternate Names | CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; |
| Description | calcium/calmodulin dependent protein kinase II beta(CAMK2B) Homo sapiens The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], |
| Cell Pathway/ Category | ErbB_HER,Calcium,Oocyte meiosis,WNT,WNT-T CELLLong-term potentiation,Neurotrophin,Olfactory transduction,GnRH,Melanogenesis,Glioma, |
| Protein Expression | Brain,Insulinoma,Lung,Skeletal muscle, |
| Subcellular Localization | nucleoplasm,microtubule organizing center,cytosol,plasma membrane,endocytic vesicle membrane,sarcoplasmic reticulum membrane, |
| Protein Function | The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |