ITM3664
ITM3664
- Catalog: ITM3664
- Gene/Protein: BECN1
- Product Description: Immunotag™ Beclin-1 mouse Monoclonal Antibody(5C5)
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Beclin-1 (5C5) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC 1:100-200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Mouse |
| Immunogen | Synthetic Peptide of Beclin-1 at AA range of 110-190 |
| Specificity | Beclin-1 protein detects endogenous levels of BECN1 |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | BECN1 |
| Accession No. | Q14457 O88597 Q91XJ1 |
| Alternate Names | BECN1 |
| Description | beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
| Cell Pathway/ Category | Regulation of autophagy, |
| Protein Expression | Brain,Cervix,Mammary gland, |
| Subcellular Localization | pre-autophagosomal structure,nucleus,mitochondrion,endosome,autophagosome,endoplasmic reticulum,endoplasmic reticulum membrane,trans-Golgi network,cytosol,endosome membrane,cytoplasmic, membrane-bounded vesicle,extrinsic component of membrane,G |
| Protein Function | function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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