ITM6016
ITM6016
ITM6016
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$541.00
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- Catalog: ITM6016
- Gene/Protein: SPN CD43
- Product Description: Immunotag™ CD43 (PT1654) mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CD43 (2B1) Clonality Monoclonal Storage/Stability -20°C/1 year Application IHC-p Recommended Dilution IHC-p 1:100-500 Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Synthesized peptide derived from human CD43 Specificity This antibody detects endogenous levels of human CD43 Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name SPN CD43 Accession No. P16150 Alternate Names Leukosialin (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) Description sialophorin(SPN) Homo sapiens The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011], Cell Pathway/ Category Cell adhesion molecules (CAMs), Protein Expression Kidney,Platelet,Spleen,T-cell,Thymus, Subcellular Localization Membranous Protein Function disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CD43 (2B1) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:100-500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Synthesized peptide derived from human CD43 |
| Specificity | This antibody detects endogenous levels of human CD43 |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SPN CD43 |
| Accession No. | P16150 |
| Alternate Names | Leukosialin (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) |
| Description | sialophorin(SPN) Homo sapiens The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Kidney,Platelet,Spleen,T-cell,Thymus, |
| Subcellular Localization | Membranous |
| Protein Function | disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |