ITM6102
ITM6102
ITM6102
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- Catalog: ITM6102
- Gene/Protein: TPO
- Product Description: Immunotag™ Thyroid Peroxidase(TPO) (ABT-TPO) mouse mAb
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein TPO (2G2) Clonality Monoclonal Storage/Stability -20°C/1 year Application IHC-p Recommended Dilution IHC-p 1:100-500 Concentration 1 mg/ml Reactive Species Human Host Species Mouse Immunogen Synthesized peptide derived from human Thyroid Peroxidase(TPO) Specificity This antibody detects endogenous levels of human Thyroid Peroxidase(TPO) Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name TPO Accession No. P07202 Alternate Names Thyroid peroxidase (TPO) (EC 1.11.1.8) Description thyroid peroxidase(TPO) Homo sapiens This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011], Cell Pathway/ Category Tyrosine metabolism,Cytokine-cytokine receptor interaction,Jak_STAT,Hematopoietic cell lineage,Autoimmune thyroid disease, Protein Expression Glandular pool- thyroid,Spleen,Thyroid, Subcellular Localization Cytoplasmic Protein Function Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:Cleaved in its N-terminal part.,PTM:Glycosylated.,PTM:Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.,similarity:Belongs to the peroxidase family. XPO subfamily.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,subunit:Interacts with DUOX1, DUOX2 and CYBA., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | TPO (2G2) |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:100-500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Synthesized peptide derived from human Thyroid Peroxidase(TPO) |
| Specificity | This antibody detects endogenous levels of human Thyroid Peroxidase(TPO) |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TPO |
| Accession No. | P07202 |
| Alternate Names | Thyroid peroxidase (TPO) (EC 1.11.1.8) |
| Description | thyroid peroxidase(TPO) Homo sapiens This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011], |
| Cell Pathway/ Category | Tyrosine metabolism,Cytokine-cytokine receptor interaction,Jak_STAT,Hematopoietic cell lineage,Autoimmune thyroid disease, |
| Protein Expression | Glandular pool- thyroid,Spleen,Thyroid, |
| Subcellular Localization | Cytoplasmic |
| Protein Function | Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:Cleaved in its N-terminal part.,PTM:Glycosylated.,PTM:Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.,similarity:Belongs to the peroxidase family. XPO subfamily.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,subunit:Interacts with DUOX1, DUOX2 and CYBA., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |