ITN0136
ITN0136
ITN0136
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- Catalog: ITN0136
- Gene/Protein: KAT6B KIAA0383 MORF MOZ2 MYST4
- Product Description: Immunotag™ KAT6B Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein KAT6B Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 1170-1250 Specificity KAT6B Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name KAT6B KIAA0383 MORF MOZ2 MYST4 Accession No. Q8WYB5 Q8BRB7 Description lysine acetyltransferase 6B(KAT6B) Homo sapiens The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012], Protein Expression Adipose,Bone marrow,Brain,Epithelium,Lung, Subcellular Localization nucleosome,nucleus,nucleoplasm,MOZ/MORF histone acetyltransferase complex, Protein Function catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,disease:A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.,domain:The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.,function:Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.,PTM:Autoacetylated.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.,tissue specificity:Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | KAT6B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1170-1250 |
| Specificity | KAT6B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | KAT6B KIAA0383 MORF MOZ2 MYST4 |
| Accession No. | Q8WYB5 Q8BRB7 |
| Description | lysine acetyltransferase 6B(KAT6B) Homo sapiens The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012], |
| Protein Expression | Adipose,Bone marrow,Brain,Epithelium,Lung, |
| Subcellular Localization | nucleosome,nucleus,nucleoplasm,MOZ/MORF histone acetyltransferase complex, |
| Protein Function | catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,disease:A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.,domain:The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.,function:Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.,PTM:Autoacetylated.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.,tissue specificity:Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |