ITN0153
ITN0153
- Catalog: ITN0153
- Gene/Protein: IBTK BTKI KIAA1417
- Product Description: Immunotag™ IBTK Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IBTK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 410-490 |
| Specificity | IBTK Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | IBTK BTKI KIAA1417 |
| Accession No. | Q9P2D0 Q6ZPR6 |
| Description | inhibitor of Bruton tyrosine kinase(IBTK) Homo sapiens Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014], |
| Protein Expression | B-cell,Brain,Epithelium,Heart,Lung,Skin, |
| Subcellular Localization | nucleoplasm,cytoplasm,membrane, |
| Protein Function | function:Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 RCC1 repeats.,subcellular location:Translocates to the plasma membrane upon IgM stimulation.,subunit:Interacts with the PH domain of BTK.,tissue specificity:Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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