ITN0197
ITN0197
- Catalog: ITN0197
- Gene/Protein: FAT1 CDHF7 FAT
- Product Description: Immunotag™ FAT1 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | FAT1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p |
Recommended Dilution | IHC-p 1:50-300 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein . at AA range: 1140-1220 |
Specificity | FAT1 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | FAT1 CDHF7 FAT |
Accession No. | Q14517 |
Description | FAT atypical cadherin 1(FAT1) Homo sapiens This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008], |
Protein Expression | Epithelium,Liver,Lymphocyte, |
Subcellular Localization | nucleus,plasma membrane,integral component of plasma membrane,cell-cell junction,focal adhesion,membrane,integral component of membrane,lamellipodium,filopodium,perinuclear region of cytoplasm,extracellular exosome, |
Protein Function | function:Could function as a cell-adhesion protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 34 cadherin domains.,similarity:Contains 5 EGF-like domains.,tissue specificity:Expressed in many epithelial and some endothelial and smooth muscle cells., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |