ITN0240
ITN0240
ITN0240
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$424.00
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- Catalog: ITN0240
- Gene/Protein: JAM3 UNQ859/PRO1868
- Product Description: Immunotag™ JAM3 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein JAM3 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from human protein, at AA range: 60-140 Specificity JAM3 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name JAM3 UNQ859/PRO1868 Accession No. Q9BX67 Q9D8B7 Q68FQ2 Description junctional adhesion molecule 3(JAM3) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Cell Pathway/ Category Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration,Epithelial cell signaling in Helicobacter pylori infection, Protein Expression Brain,Eye,Uterus, Subcellular Localization extracellular space,Golgi apparatus,plasma membrane,bicellular tight junction,integral component of membrane,desmosome,paranodal junction,Schmidt-Lanterman incisure,cell-cell contact zone, Protein Function function:May participate in cell-cell adhesion distinct from tight junctions.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with JAM2.,tissue specificity:Widely expressed. Highest expression in placenta, brain and kidney., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | JAM3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 60-140 |
| Specificity | JAM3 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | JAM3 UNQ859/PRO1868 |
| Accession No. | Q9BX67 Q9D8B7 Q68FQ2 |
| Description | junctional adhesion molecule 3(JAM3) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration,Epithelial cell signaling in Helicobacter pylori infection, |
| Protein Expression | Brain,Eye,Uterus, |
| Subcellular Localization | extracellular space,Golgi apparatus,plasma membrane,bicellular tight junction,integral component of membrane,desmosome,paranodal junction,Schmidt-Lanterman incisure,cell-cell contact zone, |
| Protein Function | function:May participate in cell-cell adhesion distinct from tight junctions.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with JAM2.,tissue specificity:Widely expressed. Highest expression in placenta, brain and kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |