ITN0269
ITN0269
ITN0269
from
$424.00
Price in reward points: 424
- Catalog: ITN0269
- Gene/Protein: CYB5R4 NCB5OR
- Product Description: Immunotag™ NB5R4 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NB5R4 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from human protein, at AA range: 380-460 Specificity NB5R4 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name CYB5R4 NCB5OR Accession No. Q7L1T6 Q3TDX8 Q68EJ0 Description cytochrome b5 reductase 4(CYB5R4) Homo sapiens NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010], Protein Expression Testis, Subcellular Localization endoplasmic reticulum,endoplasmic reticulum membrane,perinuclear region of cytoplasm, Protein Function catalytic activity:NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.,cofactor:FAD.,function:NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.,polymorphism:Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.,similarity:Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,similarity:Contains 1 CS domain.,similarity:Contains 1 cytochrome b5 heme-binding domain.,similarity:Contains 1 FAD-binding FR-type domain.,subcellular location:Soluble protein.,tissue specificity:Widely expressed., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NB5R4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 380-460 |
| Specificity | NB5R4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CYB5R4 NCB5OR |
| Accession No. | Q7L1T6 Q3TDX8 Q68EJ0 |
| Description | cytochrome b5 reductase 4(CYB5R4) Homo sapiens NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010], |
| Protein Expression | Testis, |
| Subcellular Localization | endoplasmic reticulum,endoplasmic reticulum membrane,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.,cofactor:FAD.,function:NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.,polymorphism:Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.,similarity:Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,similarity:Contains 1 CS domain.,similarity:Contains 1 cytochrome b5 heme-binding domain.,similarity:Contains 1 FAD-binding FR-type domain.,subcellular location:Soluble protein.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |