menu
Your Cart

ITN0270

  • Gene/Protein: NFAM1 CNAIP
  • Product Description: Immunotag™ NFAM1 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITN0270

Immunotag™ NFAM1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein NFAM1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 30-110
Specificity NFAM1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name NFAM1 CNAIP
Accession No. Q8NET5 Q8R4V1
Description NFAT activating protein with ITAM motif 1(NFAM1) Homo sapiens The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008],
Protein Expression Spleen,T-cell,
Subcellular Localization intracellular,plasma membrane,cell surface,integral component of membrane,membrane raft,
Protein Function domain:The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.,function:May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Partially recruited to lipid rafts upon BCR stimulation.,subunit:Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR).,tissue specificity:Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
English_US
Danish
Dutch
English_UK
French
German
Norwegian
Portuguese
Finnish
Swedish
Polish
Write a review
Note: HTML is not translated!
Bad Good
Captcha

Download our handbooks

Custom Services

Connect With Us

Stay up to date with G-Biosciences by signing up for our newsletter.