ITN0305
ITN0305
- Catalog: ITN0305
- Gene/Protein: CENPC1 CENPC ICEN7
- Product Description: Immunotag™ CENPC Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | CENPC |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein . at AA range: 160-240 |
Specificity | CENPC Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | CENPC1 CENPC ICEN7 |
Accession No. | Q03188 P49452 |
Description | centromere protein C(CENPC) Homo sapiens Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008], |
Protein Expression | Blood,Epithelium,Placenta,Testis, |
Subcellular Localization | kinetochore,condensed chromosome kinetochore,condensed nuclear chromosome kinetochore,condensed nuclear chromosome, centromeric region,nucleus,nucleoplasm,pericentric heterochromatin,cytoplasm,cytosol, |
Protein Function | disease:Antibodies against CENPC are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.,function:Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.,subcellular location:Localizes exclusively in the kinetochore domain of centromeres.,subunit:Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |