ITN0642
ITN0642
ITN0642
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- Catalog: ITN0642
- Gene/Protein: DGAT2 HMFN1045 UNQ738/PRO1433
- Product Description: Immunotag™ DGAT2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein DGAT2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity DGAT2 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name DGAT2 HMFN1045 UNQ738/PRO1433 Accession No. Q96PD7 Q9DCV3 Q5FVP8 Description diacylglycerol O-acyltransferase 2(DGAT2) Homo sapiens This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], Cell Pathway/ Category Glycerolipid metabolism,Retinol metabolism, Protein Expression Adipocyte,Hepatoblastoma,Lymph node,Pancreas,Testis,Uterus, Subcellular Localization mitochondrion,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,integral component of membrane,integral component of endoplasmic reticulum membrane,perinuclear region of cytoplasm, Protein Function catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,enzyme regulation:Inhibited by niacin.,function:Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,similarity:Belongs to the diacylglycerol acyltransferase family.,tissue specificity:Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammaray gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | DGAT2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DGAT2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DGAT2 HMFN1045 UNQ738/PRO1433 |
| Accession No. | Q96PD7 Q9DCV3 Q5FVP8 |
| Description | diacylglycerol O-acyltransferase 2(DGAT2) Homo sapiens This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Cell Pathway/ Category | Glycerolipid metabolism,Retinol metabolism, |
| Protein Expression | Adipocyte,Hepatoblastoma,Lymph node,Pancreas,Testis,Uterus, |
| Subcellular Localization | mitochondrion,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,integral component of membrane,integral component of endoplasmic reticulum membrane,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,enzyme regulation:Inhibited by niacin.,function:Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,similarity:Belongs to the diacylglycerol acyltransferase family.,tissue specificity:Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammaray gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |