ITN0650
ITN0650
ITN0650
from
$424.00
Price in reward points: 424
- Catalog: ITN0650
- Gene/Protein: CDT1
- Product Description: Immunotag™ CDT1 Polyclonal Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CDT1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity CDT1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name CDT1 Accession No. Q9H211 Q8R4E9 Description chromatin licensing and DNA replication factor 1(CDT1) Homo sapiens The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011], Protein Expression Brain,Cervix,Epithelium,Eye,Kidney,Liver,Uterus, Subcellular Localization nucleus,nucleoplasm,cytosol, Protein Function developmental stage:Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.,function:Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.,PTM:Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation.,PTM:Ubiquitinated, leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination.,similarity:Belongs to the Cdt1 family.,subunit:Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CDT1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CDT1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CDT1 |
| Accession No. | Q9H211 Q8R4E9 |
| Description | chromatin licensing and DNA replication factor 1(CDT1) Homo sapiens The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011], |
| Protein Expression | Brain,Cervix,Epithelium,Eye,Kidney,Liver,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm,cytosol, |
| Protein Function | developmental stage:Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.,function:Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.,PTM:Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation.,PTM:Ubiquitinated, leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination.,similarity:Belongs to the Cdt1 family.,subunit:Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |