ITN0670
ITN0670
ITN0670
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- Catalog: ITN0670
- Gene/Protein: DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325
- Product Description: Immunotag™ DYHC1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein DYHC1 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p Recommended Dilution IHC-p 1:50-300 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity DYHC1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 Accession No. Q14204 Q9JHU4 P38650 Description dynein cytoplasmic 1 heavy chain 1(DYNC1H1) Homo sapiens Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008], Protein Expression Brain,Epithelium,Foreskin,Lung,Placenta,Testis, Subcellular Localization centrosome,cytosol,cytoplasmic dynein complex,microtubule,membrane,filopodium,dynein complex,extracellular matrix,extracellular exosome, Protein Function domain:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.,function:Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.,similarity:Belongs to the dynein heavy chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | DYHC1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DYHC1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 |
| Accession No. | Q14204 Q9JHU4 P38650 |
| Description | dynein cytoplasmic 1 heavy chain 1(DYNC1H1) Homo sapiens Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008], |
| Protein Expression | Brain,Epithelium,Foreskin,Lung,Placenta,Testis, |
| Subcellular Localization | centrosome,cytosol,cytoplasmic dynein complex,microtubule,membrane,filopodium,dynein complex,extracellular matrix,extracellular exosome, |
| Protein Function | domain:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.,function:Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.,similarity:Belongs to the dynein heavy chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |