ITN0700
ITN0700
- Catalog: ITN0700
- Gene/Protein: NEIL2
- Product Description: Immunotag™ NEIL2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NEIL2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | NEIL2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NEIL2 |
| Accession No. | Q969S2 Q6R2P8 |
| Description | nei like DNA glycosylase 2(NEIL2) Homo sapiens NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | Base excision repair, |
| Protein Expression | Amygdala,Brain,Fetal kidney,Muscle,Testis, |
| Subcellular Localization | nucleoplasm,cytoplasm,spindle microtubule, |
| Protein Function | catalytic activity:Removes damaged bases from DNA, leaving an abasic site.,catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,domain:The zinc-finger domain is important for DNA binding.,enzyme regulation:Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no effect.,function:Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.,similarity:Belongs to the FPG family.,similarity:Contains 1 FPG-type zinc finger.,subunit:Binds EP300.,tissue specificity:Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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