ITN0735
ITN0735
- Catalog: ITN0735
- Gene/Protein: GPSM2 LGN
- Product Description: Immunotag™ GPSM2 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | GPSM2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | GPSM2 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | GPSM2 LGN |
Accession No. | P81274 Q8VDU0 |
Description | G-protein signaling modulator 2(GPSM2) Homo sapiens The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
Protein Expression | B-cell,Brain,Muscle, |
Subcellular Localization | spindle pole,cytoplasm,cell cortex,apical part of cell,mitotic spindle pole, |
Protein Function | function:Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.,miscellaneous:Dysfunction of LGN is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic splindle regulator protein NuMA.,similarity:Belongs to the GPSM family.,similarity:Contains 4 GoLoco domains.,similarity:Contains 8 TPR repeats.,subcellular location:Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.,subunit:Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2.,tissue specificity:Ubiquitously expressed., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |