ITN0947
ITN0947
ITN0947
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$424.00
Price in reward points: 424
- Catalog: ITN0947
- Gene/Protein: UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692
- Product Description: Immunotag™ UNC5D Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein UNC5D Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 160-240 Specificity UNC5D Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692 Accession No. Q6UXZ4 Q8K1S2 Description function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC., Cell Pathway/ Category Axon guidance, Protein Expression Brain,Epithelium, Subcellular Localization plasma membrane,cell surface,integral component of membrane, Protein Function function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | UNC5D |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 160-240 |
| Specificity | UNC5D Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692 |
| Accession No. | Q6UXZ4 Q8K1S2 |
| Description | function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC., |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | plasma membrane,cell surface,integral component of membrane, |
| Protein Function | function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |