ITN0999
ITN0999
ITN0999
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$424.00
Price in reward points: 424
- Catalog: ITN0999
- Gene/Protein: NR0B2 SHP
- Product Description: Immunotag™ NR0B2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NR0B2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein, at AA range: 30-110 Specificity NR0B2 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name NR0B2 SHP Accession No. Q15466 Q62227 P97947 Description nuclear receptor subfamily 0 group B member 2(NR0B2) Homo sapiens The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008], Protein Expression Pancreas,Spleen, Subcellular Localization nucleus,nucleoplasm,cytoplasm,protein complex, Protein Function disease:Defects in NR0B2 may be associated with early-onset obesity [MIM:601665].,function:Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.,similarity:Belongs to the nuclear hormone receptor family. NR0 subfamily.,subunit:Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A.,tissue specificity:Liver. Low levels of expression were detected in heart and pancreas., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NR0B2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 30-110 |
| Specificity | NR0B2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NR0B2 SHP |
| Accession No. | Q15466 Q62227 P97947 |
| Description | nuclear receptor subfamily 0 group B member 2(NR0B2) Homo sapiens The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008], |
| Protein Expression | Pancreas,Spleen, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,protein complex, |
| Protein Function | disease:Defects in NR0B2 may be associated with early-onset obesity [MIM:601665].,function:Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.,similarity:Belongs to the nuclear hormone receptor family. NR0 subfamily.,subunit:Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A.,tissue specificity:Liver. Low levels of expression were detected in heart and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |