ITN1042
ITN1042
- Catalog: ITN1042
- Gene/Protein: PI4K2A
- Product Description: Immunotag™ P4K2A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | P4K2A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 50-130 |
| Specificity | P4K2A Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PI4K2A |
| Accession No. | Q9BTU6 Q2TBE6 Q99M64 |
| Description | phosphatidylinositol 4-kinase type 2 alpha(PI4K2A) Homo sapiens Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008], |
| Protein Expression | Amygdala,Epithelium,Skin, |
| Subcellular Localization | mitochondrion,lysosomal membrane,endosome,Golgi apparatus,cytosol,integral component of plasma membrane,membrane,cell junction,dendrite,synaptic vesicle membrane,BLOC-1 complex,intrinsic component of memb |
| Protein Function | catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.,function:Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells.,similarity:Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.,similarity:Contains 1 PI3K/PI4K domain.,subcellular location:Found in subdomains of the plasma membrane termed non-caveolar membrane rafts.,tissue specificity:Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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