ITN1054
ITN1054
- Catalog: ITN1054
- Gene/Protein: PIK3R6 C17orf38
- Product Description: Immunotag™ PI3R6 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | PI3R6 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein . at AA range: 280-360 |
Specificity | PI3R6 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | PIK3R6 C17orf38 |
Accession No. | Q5UE93 Q3U6Q4 |
Description | phosphoinositide-3-kinase regulatory subunit 6(PIK3R6) Homo sapiens Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014], |
Protein Expression | Stomach, |
Subcellular Localization | cytosol,plasma membrane,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IB,membrane, |
Protein Function | function:Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by G beta gamma proteins.,subunit:Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. Also interacts with PDE3B and G beta gamma proteins. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |