Datasheet |
|
Target Protein |
RPGF2 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,ELISA |
Recommended Dilution |
WB 1:500-2000 ELISA 1:5000-20000 |
Concentration |
1 mg/ml |
Reactive Species |
Human,Rat,Mouse |
Host Species |
Rabbit |
Immunogen |
Synthesized peptide derived from human protein, at AA range: 190-270 |
Specificity |
RPGF2 Polyclonal Antibody detects endogenous levels of protein. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name |
RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 |
Accession No. |
Q9Y4G8 Q8CHG7 F1M386 |
Description |
Rap guanine nucleotide exchange factor 2(RAPGEF2) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008], |
Cell Pathway/ Category |
MAPK_ERK_Growth,MAPK_G_Protein, |
Protein Expression |
Brain,Platelet,Uterus, |
Subcellular Localization |
intracellular,cytoplasm,late endosome,cytosol,plasma membrane,integral component of plasma membrane,cell-cell junction,bicellular tight junction,membrane,apical plasma membrane,endocytic vesicle,neuron pr |
Protein Function |
function:Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Ras-GEF domain.,subcellular location:Associated with the synaptic plasma membrane.,subunit:Interacts with MAGI2.,tissue specificity:Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |