ITN1155
ITN1155
- Catalog: ITN1155
- Gene/Protein: RASGRP3 GRP3 KIAA0846
- Product Description: Immunotag™ GRP3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GRP3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | GRP3 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | RASGRP3 GRP3 KIAA0846 |
| Accession No. | Q8IV61 |
| Description | RAS guanyl releasing protein 3(RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,B_Cell_Antigen, |
| Protein Expression | Brain, |
| Subcellular Localization | intracellular,plasma membrane,integral component of plasma membrane,guanyl-nucleotide exchange factor complex,perinuclear region of cytoplasm, |
| Protein Function | function:Guanine nucleotide exchange factor (GEF) for Ras and Rap1.,similarity:Belongs to the RASGRP family.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 EF-hand domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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