ITN1162
ITN1162
ITN1162
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$424.00
Price in reward points: 424
- Catalog: ITN1162
- Gene/Protein: RAC2
- Product Description: Immunotag™ RAC2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RAC2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 130-210 Specificity RAC2 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name RAC2 Accession No. P15153 Q05144 Description ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)(RAC2) Homo sapiens This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013], Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Chemokine,WNT,WNT-T CELLAxon guidance,VEGF,Focal adhesion,Adherens_Junction,Natural killer cell mediated cytotoxicity,B_Cell_Antigen,Fc epsilon RI,Fc gamma R-mediated phagocytosis,Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton,Pathways in cancer,Colorectal cancer,Pancreatic cancer,Viral myocarditis, Protein Expression Brain, Subcellular Localization intracellular,nuclear envelope,cytoplasm,cytosol,actin filament,plasma membrane,focal adhesion,membrane,lamellipodium,phagocytic vesicle membrane,extracellular exosome, Protein Function disease:Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203].,enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.,function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of the NADPH oxidase.,online information:RAC2 mutation db,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated.,subunit:Interacts with DOCK2, which may activate it.,tissue specificity:Hematopoietic specific., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RAC2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Specificity | RAC2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | RAC2 |
| Accession No. | P15153 Q05144 |
| Description | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)(RAC2) Homo sapiens This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Chemokine,WNT,WNT-T CELLAxon guidance,VEGF,Focal adhesion,Adherens_Junction,Natural killer cell mediated cytotoxicity,B_Cell_Antigen,Fc epsilon RI,Fc gamma R-mediated phagocytosis,Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton,Pathways in cancer,Colorectal cancer,Pancreatic cancer,Viral myocarditis, |
| Protein Expression | Brain, |
| Subcellular Localization | intracellular,nuclear envelope,cytoplasm,cytosol,actin filament,plasma membrane,focal adhesion,membrane,lamellipodium,phagocytic vesicle membrane,extracellular exosome, |
| Protein Function | disease:Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203].,enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.,function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of the NADPH oxidase.,online information:RAC2 mutation db,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated.,subunit:Interacts with DOCK2, which may activate it.,tissue specificity:Hematopoietic specific., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |