ITN1163
ITN1163
ITN1163
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$424.00
Price in reward points: 424
- Catalog: ITN1163
- Gene/Protein: RAC3
- Product Description: Immunotag™ RAC3 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RAC3 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 80-160 Specificity RAC3 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name RAC3 Accession No. P60763 P60764 Description ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)(RAC3) Homo sapiens The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015], Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,WNT,WNT-T CELLAxon guidance,VEGF,Focal adhesion,Adherens_Junction,Natural killer cell mediated cytotoxicity,B_Cell_Antigen,Fc epsilon RI,Regulates Actin and Cytoskeleton,Pathways in cancer,Colorectal cancer,Pancreatic cancer,Viral myocarditis, Protein Expression Brain, Subcellular Localization intracellular,cytosol,plasma membrane,endomembrane system,lamellipodium,growth cone,filamentous actin,neuron projection,neuronal cell body,perinuclear region of cytoplasm,extr Protein Function function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RAC3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 80-160 |
| Specificity | RAC3 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | RAC3 |
| Accession No. | P60763 P60764 |
| Description | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)(RAC3) Homo sapiens The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,WNT,WNT-T CELLAxon guidance,VEGF,Focal adhesion,Adherens_Junction,Natural killer cell mediated cytotoxicity,B_Cell_Antigen,Fc epsilon RI,Regulates Actin and Cytoskeleton,Pathways in cancer,Colorectal cancer,Pancreatic cancer,Viral myocarditis, |
| Protein Expression | Brain, |
| Subcellular Localization | intracellular,cytosol,plasma membrane,endomembrane system,lamellipodium,growth cone,filamentous actin,neuron projection,neuronal cell body,perinuclear region of cytoplasm,extr |
| Protein Function | function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |