ITN1210
ITN1210
ITN1210
from
$424.00
Price in reward points: 424
- Catalog: ITN1210
- Gene/Protein: RBBP6 P2PR PACT RBQ1 My038
- Product Description: Immunotag™ RBBP6 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RBBP6 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 270-350 Specificity RBBP6 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name RBBP6 P2PR PACT RBQ1 My038 Accession No. Q7Z6E9 P97868 Description RB binding protein 6, ubiquitin ligase(RBBP6) Homo sapiens The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Protein Expression Amygdala,Bone,Epithelium,Fetal brain,Kidney,Liver,Pancreas,PCR resc Subcellular Localization nucleus,nucleoplasm,chromosome,nucleolus,microtubule organizing center,cytosol, Protein Function PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Intron retention.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 DWNN domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Colocalizes with mitotic chromosomes.,subunit:Interacts with p53/TP53 and RB1.,tissue specificity:Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RBBP6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 270-350 |
| Specificity | RBBP6 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | RBBP6 P2PR PACT RBQ1 My038 |
| Accession No. | Q7Z6E9 P97868 |
| Description | RB binding protein 6, ubiquitin ligase(RBBP6) Homo sapiens The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Protein Expression | Amygdala,Bone,Epithelium,Fetal brain,Kidney,Liver,Pancreas,PCR resc |
| Subcellular Localization | nucleus,nucleoplasm,chromosome,nucleolus,microtubule organizing center,cytosol, |
| Protein Function | PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Intron retention.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 DWNN domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Colocalizes with mitotic chromosomes.,subunit:Interacts with p53/TP53 and RB1.,tissue specificity:Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |