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  • Gene/Protein: SVIL
  • Product Description: Immunotag™ SVIL Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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Immunotag™ SVIL Polyclonal Antibody
Antibody Specification
Target Protein SVIL
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity SVIL Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name SVIL
Accession No. O95425 Q8K4L3
Description supervillin(SVIL) Homo sapiens This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016],
Protein Expression Cervix carcinoma,Epithelium,Esophagus tumor,Kidney,Platelet,Skin and meninges pool- skin,Ut
Subcellular Localization podosome,nucleus,cytoplasm,plasma membrane,focal adhesion,actin cytoskeleton,midbody,cleavage furrow,microtubule minus-end,costamere,invadopodium,
Protein Function function:Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 1 HP (headpiece) domain.,similarity:Contains 5 gelsolin-like repeats.,subcellular location:Tightly associated with both actin filaments and plasma membranes.,subunit:Binds to F-actin.,tissue specificity:Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 2 (archvillin) is muscle specific.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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